For some strange reason the camera pixel size is often reported as 640x480, regardless of what size the camera actually is. This causes the anchors to move to odd positions, especially when switching between the game and scene views. I was able to make it work a little better by commenting out the UpdateTransform call inside tk2dCameraAnchor.LateUpdate, but..
Let me guess, this is something silly that Unity does that there's no way to work around, right?