Yes.
Use the tk2dCamara for this. If you want it to be pixel perfect, make sure to set filtering type to Point and on the tk2dCamera set AutoScaleMode to PixelPerfectFit. This will rescale your native game to the closest round number multiple.
If you want you can letterbox the remainder and whats outside the viewport. If your game supports it, you can simply display more information.
You can also use platform specific sprite collections to replace textures with higher resolution versions if you like.
Finally if you need even more control, you can use something like Owlchemy Labs' Multiplatform toolkit to reposition things on different platforms, etc.