How are you defining the box collider?
If you want to detect collisions between hand and other parts of enemy, your best bet might be...
1. Create a sprite, use character controller, or whatever you like here.
2. Use the attach point feature to mark out the arm / leg, etc. (Check
http://unikronsoftware.com/2dtoolkit/doc/2.20/reference/sprite_attach_point.html for more info).
3. Create sprites to use the above.
You will now have these game obejcts animating properly - you can attach normal Unity rigidbodies / shapes there to say "this is the hand" and so on, tagged as triggers if you need it - if you just need to find out if you hit something, triggers are better than colliders.