Hello
I am having the same issue. Specifically when trying to set the "Auto scale" dropdown value on my wildcard override. It keeps going back to "Closest Multiple of 2", even though I set it to "Fit width" and save, and have done so multiple times. I just tested the solution posted by OP, that "If you toggle the tk2dcamera component or gameobject off/on, though, the scene then seems to marked dirty." It works perfectly.