Re-reading your post... when you say the animation is down and to the left, do you mean it is 'down and to the left' of the mole that you hit, or it is in the bottom left of the game screen all of the time? If it's the former, also check the anchor position on the Mole sprites as well, which I've used middle-center for mine. If the animation is the bottom left of the screen all of the time, have you added the MainGame script to the scene?